PUBLICATIONS

Publications

Our research and development achievements are published in leading international peer-reviewed journals, spanning mRNA platform technology, infectious disease vaccines, therapeutic proteins, and gene editing.

Project

Year

Enhanced immunogenicity and dose-sparing efficacy of self-amplifying RNA vaccines against seasonal influenza across subtypes.

Authors:Mengting Huang*, Yun Quan*, Ruyi Chen*, Hao Gu*, Wenjun Song, Feng Zhu, Simin Feng, Jinzhong Lin, Jing Lu, Xuechun Li, Wansheng Li, Qianyu Pan, Hongli Li, Lei Sun, Tao Jiang, Bihui Zhang, Xinqian Yin, Dandan Wei, Changrong Yang, Donglan Liu, Zhongfang Wang, Weixin Jia, Jincun Zhao, Jieshi Yu, Xiaobo Li, Xuedong Yu, Xiaojing Yue, Chufang Li, Fan Bu, Zhichao Miao and Qiong ZhangJournal:Emerging Microbes & Infections | Emerging Microbes & Infections, 2026, Vol. 15, 2668752 (20 pages)

Preclinical evaluation of an mRNA vaccine developed from the first human isolate of bovine H5N1.

Authors:Hongli Li, Mengting Huang, Simin Feng, Wansheng Li, Dandan Wei, Xuechun Li, Yun Quan, Hao Gu, Ting Jiang, Yan Liu, Jing Lu, Wenjun Song, Xinkui Zhang, Yujia Yang, Qianyu Pan, LinLei Chen, Jingyou Yu, Hantao Lou, Mengyi Zhang, Youchun Wang, Kelvin Kai-Wang To, Weixin Jia*, Jinzhong Lin*, and Qiong ZhangJournal:Cell Reports Medicine | Cell Reports Medicine, Volume 7, Issue 4, 21 April 2026, 102702

Modified mRNA treatment restores cardiac function in desmocollin-2-deficient mouse models of arrhythmogenic right ventricular cardiomyopathy.

Authors:Zou, Y.*, Lu, J.*, Lian, Z.*, Jia, J.*, Shen, J.*, Li, Q., Wong, J.M.J., Jin, K., Yan, W., Ren, X., Zhang, Y., Huang, C., Yang, H., Huang, F., Li, J., Zhai, J., Xu, Y., Xu, X., Yu, H., Jin, Y., Gong, H., Lin, J., Ge, J., and Dai, YJournal:Circulation | Circulation, 151, 1780–1796 (2025). (* co-first author)

In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type I Interferon Signaling in Monocytes.▼

Authors:Li H, Lu J, Tan S, Jiang T, He X, Qiao W, Hu C, Dalangood S, Lin J, Gui JJournal:Cancer Immunol Res. | Cancer Immunol Res. 2025 Jun 4;13(6):939-956

Hydroxychloroquine-functionalized ionizable lipids mitigate inflammatory responses in mRNA therapeutics.▼

Authors:Chen K, Li X, Feng S, Li Y, Jiang T, Liu Y, Guo N, Zeng X, Yao H, Qiu M, Lu J, Lin JJournal:J Control Release. | J Control Release. 2025 Nov 10;387:114267

Efficacy, immunogenicity, and safety of heterologous boosting with a novel chimera Chinese mRNA (RQ3013) SARS-CoV-2 vaccine: A randomized, double-blind, active-controlled trial.

Authors:Liu XQ, Qi YY, Huang T, Huang LL, Zhao MX, Wang ZF, Dai J, Wang YX, Chen JJ, Yang XY, Fan HL, Yan XM, He JC, Zou YX, Jiang ZW, Zhan ZF, Tao SW, Dai DF, Shi F, Zhang QN, Yang XL, Li XZ, Li W, Lu J, Zheng JB, Zhang ZH, Chen GX, Su H, Gao WM, Seidlein LV, Wang XY, Yuan L, Lin JZJournal:Hum Vaccin Immunother | Hum Vaccin Immunother. 2025 Dec;21(1):2502250

The mRNA vaccine encoding Gc protein confers complete protection against severe fever with thrombocytopenia syndrome virus.

Authors:Zhang X, Zhang X, Lu J, Yang P, Lu M, Tan S, Guo W, Hu X, Lin J, Shan CJournal:Vaccine | Vaccine. 2025 Sep 17;63:127631

Codelivery of NGFR100W and VEGFA mRNA Enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy.

Authors:Wang W, Yu X, Yang Z, Zhang Y, Yang W, Xu Y, Xu WJournal:Diabetes | Diabetes. 2025 Aug 1;74(8):1427-1440

Development of a dissolving microneedle patch for transdermal delivery of SARS-CoV-2 mRNA vaccine with enhanced stability and immunogenicity.▼

Authors:Tang Z, Su T, Jiang T, Hu J, Chen D, Li X, Lu J, Lin J, Shen TJournal:J Control Release. | J Control Release. 2025 Dec 10;388(Pt 1):114263

Deep learning analysis of urine-derived stem cell mitochondrial morphology as a non-invasive Alzheimer's disease biomarker.▼

Authors:Yan R, Zhang W, Wang W, Wu J, Zhang J, Xu Y, Xu W, Yang WJournal:Neurotherapeutics. | Neurotherapeutics. 2025 Dec 16:e00813

Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studies.

Authors:Lu, J.*#, Tan, S.*, Gu, H.*, Liu, K.*, Huang, W., Yu, Z., Lu, G., Wu, Z., Gao, X., Zhao, J., Yao, Z., Yi, F., Yang, Y., Wang, H., Hu, X., Lu, M., Li, W., Zhou, H., Yu, H., Shan, C.#, and Lin, J.#Journal:Emerg. Microbes Infect. | Emerg. Microbes Infect. 13, 2321994 (2024). (*# co-first and corresponding author)

Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery.

Authors:Wang, W., Chen, K., Jiang, T., Wu, Y., Wu, Z., Ying, H., Yu, H., Lu, J., Lin, J.#, and Ouyang, D.#Journal:Nat. Commun. | Nat. Commun. 15, 10804 (2024)

mRNA-encoded fluorescent proteins enable superior organelle labeling for live cell imaging.

Authors:Wang J, Cao Z, Zhang Q, Yu X, Lan Z, Zhao L, Wang J, Wang W, Zhang Y, Zhong Z, Hou Y, He X, An Z, Yu H, Xu Y, Yang WJournal:FASEB J. | FASEB J. 2024 Dec 15;38(23):e70244

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants.

Authors:Tan, S., Zhao, J., Hu, X., Li, Y., Wu, Z., Lu, G., Yu, Z., Du, B., Liu, Y., Li, L., Chen, Y., Li, Y., Yao, Y., Zhang, X., Rao, J., Gao, G., Peng, Y., Liu, H., Yuan, Z., Liu, J., Wang, Q., Hu, H., Gao, X., Zhou, H., Yu, H., Xu, Y., Yu, W., Feng, L., Wang, M., Shan, C., Lu, J.#, and Lin, J.#Journal:Sci. Bull. (Beijing) | Sci. Bull. (Beijing) 68, 3192–3206 (2023). (# co-corresponding author)

Dual ethanolamine head groups in ionizable lipids facilitate phospholipid-free stable nanoparticle formulation for augmented and safer mRNA delivery.

Authors:Lu, J.*, Jiang, T.*, Li, X., Tan, S., Zhang, Y., Gu, H., Chen, L., Guo, J., Yu, R., Zang, J., Ouyang, D., Yu, H., Yao, H., Qiu, M., and Lin, JJournal:bioRxiv | bioRxiv 2023.10.13.562139. (* co-first author)

Safety, immunogenicity, and efficacy of an mRNA COVID-19 vaccine (RQ3013) given as the fourth booster following three doses of inactivated vaccines: A double-blinded, randomised, controlled, phase 3b trial.

Authors:Liu, X., Sun, Z., Wang, Z., Chen, J., Wu, Q., Zheng, Y., Yang, X., Mo, L., Yan, X., Li, W., Zou, Y., Song, H., Qian, F., Lu, J., Zhou, H., Wang, Y., Xiang, Z., Yu, H., Lin, J., Yuan, L., and Zheng, YJournal:EClinicalMedicine | EClinicalMedicine 64, 102231 (2023)

The screening of broadly neutralizing antibodies targeting the SARS-CoV-2 spike protein by mRNA immunization in mice.

Authors:An, Z., Zhang, Y., Yu, X., Xia, J., Yin, Y., Li, G., Lu, J., Fan, X., and Xu, YJournal:Pharmaceutics | Pharmaceutics 15, 1412 (2023)

Optimization of Strategy for Modified mRNA Inducing Cardiac-Specific Expression in Mice.

Authors:Huang C, Jia J, Jin K, Zou Y, Tan S, Lu J, Zhu Y, Lin J, Dai Y, Gong HJournal:J Cardiovasc Transl Res. | J Cardiovasc Transl Res. 2023 Oct;16(5):1078-1084

Lipid Nanoparticle Delivery of Chemically Modified NGFR100W mRNA Alleviates Peripheral Neuropathy.

Authors:Yu X, Yang Z, Zhang Y, Xia J, Zhang J, Han Q, Yu H, Wu C, Xu Y, Xu W, Yang WJournal:Adv Healthc Mater. | Adv Healthc Mater. 2023 Jan;12(3):e2202127

Application of Lung-Targeted Lipid Nanoparticle-delivered mRNA of soluble PD-L1 via SORT Technology in Acute Respiratory Distress Syndrome.

Authors:Sun H, Zhang Y, Wang J, Su J, Zhou D, Yu X, Xu Y, Yang WJournal:Theranostics. | Theranostics. 2023 Sep 4;13(14):4974-4992

Alleviation of ischemia-reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles.

Authors:Hou Y, Lin S, Xia J, Zhang Y, Yin Y, Huang M, Xu Y, Yang W, Zhu YJournal:Mol Ther Nucleic Acids. | Mol Ther Nucleic Acids. 2023 Oct 26;34:102067

Chemically modified in-vitro-transcribed mRNA encoding thrombopoietin stimulates thrombopoiesis in mice.

Authors:Zhang Y, Xi X, Yu H, Yang L, Lin J, Yang W, Liu J, Fan X, Xu YJournal:Mol Ther Nucleic Acids. | Mol Ther Nucleic Acids. 2022 Aug 13;29:657-671

opvCRISPR: One-pot visual RT-LAMP-CRISPR platform for SARS-cov-2 detection.

Authors:Wang R, Qian C, Pang Y, Li M, Yang Y, Ma H, Zhao M, Qian F, Yu H, Liu Z, Ni T, Zheng Y, Wang YJournal:Biosens Bioelectron. | Biosens Bioelectron. 2021 Jan 15;172:112766

A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice.

Authors:Lu J, Lu G, Tan S, Xia J, Xiong H, Yu X, Qi Q, Yu X, Li L, Yu H, Xia N, Zhang T, Xu Y, Lin JJournal:Cell Res. | Cell Res. 2020 Oct;30(10):936-939